Discussion
Diagnosis With Brief Discussion
- Diagnosis
- Fat embolism syndrome
- Radiologic Findings
- Fig. 1. Chest anteroposterior radiograph showing diffuse and patchy increased opacities in both lung fields.
Figs. 2–5. Chest computed tomography scans showing multifocal patchy ground-glass opacities resulting in a geographic appearance without a predominant distribution. No filling defects are seen in the pulmonary artery.
- Brief Review
- The patient had a fracture in the right femoral neck due to a slip down.
Bronchoalveolar lavage analysis revealed oil red O-positive lipid globules in histiocytes (fat embolism clinically).
Fat embolism is an infrequent complication of long bone fractures, occurring in 1%–3% of patients with simple tibial or femoral fractures but in up to 20% of patients with more severe trauma. Its less common causes include hemoglobinopathy, major burns, pancreatitis, overwhelming infection, tumors, blood transfusion, and liposuction.
The first mechanism is the production of free fatty acids, which initiate a toxic and inflammatory reaction in the endothelium. Vessel wall permeability is increased, and extravasations, interstitial hemorrhage, and alveolar wall damage with passage of blood and fat microglobules into the alveoli occur. The second mechanism is the mechanical obstruction of the pulmonary vasculature by fat globules and aggregates of red blood cells and platelets.
A combination of pulmonary, cerebral, and cutaneous symptoms typically occurs within 12–24 h of the traumatic event. Chest imaging shows bilateral homogeneous and heterogeneous opacities and resolves within 1 week. The time interval between the traumatic event and radiographic abnormalities is usually 1–2 days, which allows differentiation from traumatic contusion.
The radiographic findings resemble those of acute respiratory distress syndrome from any cause and consist of widespread homogeneous and heterogeneous areas of increased opacity.
- Please refer to
Case 837, Case 449, Case 297, Case 257, -
KSTR imaging conference 2017 Spring Case 10
,
KSTR Imaging Conference 2014 Summer Case 2
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KSTR Imaging Conference 2005 Summer Case 2
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KSTR Imaging Conference 2004 Spring Case 4,
- References
- 1. Han D, Lee KS, Franquet T, et al. Thrombotic and nonthrombotic pulmonary arterial embolism: spectrum of imaging findings. Radiographics. 2003;23:1521-1539.
2. Georgopoulos D, Bouros D. Fat embolism syndrome: clinical examination is still the preferable diagnostic method. Chest. 2003;123:982-983.
- Keywords